Hydrocodone

Hydrocodone is a narcotic analgesic agent, as well as an antitussive, which is used as the treatment of both respectively moderate to severe pain, and cough suppression. This semi-synthetic opioid is also known as dihydrocodeinone. People used to buy Hydrocodone online under several brand names of generic Hydrocodone like Vicodin, Lortab, etc. It has also the extended-release form, marketed as Zohydro ER, and Hysingla ER.

Use Of Hydrocodone

Hydrocodone is a prescription medicine, available both in oral, and liquid form. The liquid formulation of Hydrocodone is used as a cough suppressant. Oral Hydrocodone is mainly used to treat mild to severe-level pain. This medication is dispensed along with other different compounds and analgesics. It can be found in the following oral forms:

Hydrocodone takes 20-30 minutes to begin its effects and long lasts up to 4-8 hours. Approximately after one hour after taking hydrocodone, it reaches the peak point. It is best to maintain 4-6 hours of time gap for the next dose.

How and Where to Buy Hydrocodone Online

No doubt Hydrocodone is one of the most demanding pain medications for the range of moderate to severe pain. But because of its abusive nature, it can only be available, if you have a valid doctor’s prescription. If you are willing to buy Hydrocodone online with prescription using different payment modes like credit card, online banking, and debit card, then here is the way to purchase Hydrocodone online from BigPharmaUSA;

• Welcome to the ‘BigpharmaUSA’ website, you are already on the ‘Hydrocodone’ page.
• Now choose the right dose as per your doctor’s prescription, among all Hydrocodone dosages.
• Click on ‘Buy Now’.
• Select the pill quantity, and click on the ‘Add To Cart’ button.
• Go for the ‘View Cart’ option, if you have multiple items to purchase. Or go to the ‘Check Out’ option.
• Fill out the ‘Billing Details’, and click on the ‘Place Order’ option.

Contraindications Conditions

Usage of Hydrocodone under certain medical conditions is prohibited. You must inform your doctor if you have any of these health conditions:

• Problems with breathing, sleep apnea
• A weaker pulse or a slowed heart rate
• Irritation while urinating
• Confusion
• Tremors and shaking
• Severe drowsiness
• Feeling lightheaded
• Nausea, vomiting, and diarrhea
• Low cortisol levels
• High levels of serotonin in the system
• Hypersensitivity to Hydrocodone
• Bronchial asthma

Hydrocodone’s Mechanism

Hydrocodone is an opioid receptor agonist that produces analgesic effects by activating mu-opioid receptors. It tends to activate delta-opioid receptors and kappa-opioid receptors present in an individual’s brain. Opioid receptors are primarily found within the central nervous system, in the enteric plexus, interstitial cells of Cajal, and immune cells present in the gastrointestinal tract.

Pharmacokinetics of Hydrocodone

Hydrocodone like all other medicines is metabolized in the liver. The cytochrome P450 enzymes CYP2D6 and CYP3A4 convert Hydrocodone to its active metabolite, hydromorphone. Clinical studies have observed that pain relief is correlated with plasma concentrations of hydromorphone rather than hydrocodone.

Hydrocodone IR (Immediate Release) and ER (Extended Release) reach peak concentration within 1 hour and 5-30 hours, respectively. The half-life elimination of Hydrocodone IR and ER is approximately 4 hours and 7-12 hours, respectively. Hydrocodone and its metabolites are ejected from the system via the urine.

Dosage and Usage

Hydrocodone medicine is available in various formulations depending on the manufacturer. Currently, Hydrocodone is supplied in the form of:

• Oral tablets
• Capsules
• Oral solutions

Tablets and capsules are not meant to be crushed, chewed, or dissolved while ingesting the dose. This may lead to uncontrolled rapid medication delivery in the system and eventually, an overdose may cause.

This medication is available in different variants for the convenience of its users. In the present day, Hydrocodone is supplied by BigpharmaUSA in the following variants:

• Hydrocodone 10-325 mg
• Hydrocodone 10-500 mg
• Hydrocodone 10-650 mg
• Hydrocodone 10-660 mg
• Hydrocodone 5-325 mg

Geriatric dosage:

1-2 tablets of Hydrocodone 5/325 mg are prescribed to be taken every 4–6 hours. The maximum dosage should not exceed 8 tablets in a day.

Adult dosage:

1 tablet of 10/325 mg of Hydrocodone is the typical dosage for adult usage. The maximum dosage to be taken per day is 6 tablets.

In order to get Hydrocodone in your desired doses, you can either buy it from the nearest medical stores or check at online pharmacies.

Overdose

Overdosing on Hydrocodone is totally possible. An overdose can be defined as a situation of taking too much medicine or taking a higher dose other than prescribed. Symptoms of an overdose may include:

• Slowed breathing
• Difficulty during breathing
• Excessive sleepiness
• Muscle weakness
• Cold and clammy skin
• Dilated pupils
• Nausea and vomiting
• Sweating
• Fatigue
• Low blood pressure
• Possible coma
• Liver failure, etc.

Common Side Effects of Hydrocodone:

• Constipation, nausea, and vomiting
• Extreme drowsiness
• Headache
• Stuffy nose, sneezes, and a sore throat
• Abdominal cramps
• Dry mouth
• Tiredness
• Severe back pain
• Muscle twitching
• Buzzing in the ears
• difficulty falling asleep or staying asleep
• Swelling of feet, joints, or ankle
• Uncontrollable tremors

Drug Interactions

Taking certain drugs with Acetaminophen-Hydrocodone mixed medicine may increase the risks of getting drowsiness, dizziness, tiredness, and decreased physical and mental functionality like serious side effects. It is highly recommended to consult your concerned doctor about your medical history and the drugs that u have used. The prescription needs to be strictly followed while buying Hydrocodone.

• Other opioid medications like Methadone, Oxycodone, Opana ER, Oxycontin, Dilaudid, etc.
• Antihistamines
• Antipsychotics
• Benzodiazepines like Valium, Alprazolam, Lorazepam, Xanax, and Klonopin
• Tranquilizers or sleep-promoting medicines like Ambien, Lunesta, Restoril, etc.

Hydrocodone During Pregnancy

The use of Hydrocodone is not contraindicated during pregnancy but it can be fatal since opioids can cross the placenta. And prolonged usage of Hydrocodone during pregnancy may lead to neonatal opioid withdrawal syndrome (NOWS). Patients using Hydrocodone during pregnancy must receive counseling on the risks associated with opioid usage.

There is also a risk of neonatal drowsiness, depression of the CNS, and even death of the newborn baby among breastfeeding mothers who use Hydrocodone. Infants are sensitive to even the smallest dose of opioids.

Dependence and Addiction

Hydrocodone medication is introduced for a short period only. However, due to the addictive nature of opioids, when an individual uses Hydrocodone regularly ends up forming a habit of it. Once the individual becomes dependent on Hydrocodone to feel normal, trying to quit the medicine will result in withdrawal symptoms.

Addiction is a chronic, neurobiological disease that is described by behaviors such as the inability to control drug use, continuous usage despite its negative impacts in life, and continuous cravings.

Withdrawal Effects:

• Anxiety and agitation
• Diarrhea
• Dilated pupils
• Severe Fever
• Insomnia
• Depression
• Pain in joints and muscles
• Nausea and vomiting
• Runny nose
• Sweating, etc.

To mitigate withdrawal conditions, individuals must treat their Hydrocodone addiction through detox, therapy, and rehab under the supervision of a substance abuse counselor or addiction counselor.