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It would not be wrong to say Opana ER is one of the most demanded medicine on our Bigpharma USA online platform. Thousands of people buy Opana ER online with a prescription from our website on daily basis. Opana ER is a great medicine popularly used to cure moderate to severe pain originating in the body due to any severe accident or surgery. We shall discuss more on Opana ER medicine as we proceed.

More Details on Opana ER

Opana ER medicine contains the primary drug Oxymorphone in its extended-release form. Due to the presence of Oxymorphone, Opana ER is classified as a Schedule II controlled substance drug. Hence, Opana ER can only be obtained with a valid prescription.

Oxymorphone extended-release tablets or Opana ER tablets are great opioid analgesic medications used by millions worldwide. These pills can be habit forming so they must be used wisely for a short period of time.

Doses and Usage

Opana ER medication is directed to be taken orally without food, usually every 12 hours in a single day. The pills are not meant to be broken, chewed, dissolved, or crushed. Rather the tablets should be swallowed as a whole with a glass of water.

Do not try to pre-soak or wet the tablets before intaking them. One tablet must be taken at a time with enough water.

Adult Dosage of Opana ER

Initially, Opana ER 5 mg tablets are recommended orally every 12 hours to treat chronic and acute pain.

Adult Dosage of Opana ER for Non-Opioid Tolerant Patients

The starting dose of Opana ER 5 mg pills is advised for patients who are not tolerant to opioids. It is to be taken orally every 12 hours.

Using higher doses at the beginning on patients who are not opioid tolerant may cause fatal respiratory problems.

Adult Dosage to Convert from Opana to Opana ER

Patients wishing to switch from Opana to Opana ER medicine can administer half the total daily oral dose of Opana as Opana ER.

These doses can be further adjusted by the concerned doctor depending on how your system is affected by the usage of the Opana ER drug. So, always try to buy Opana ER online or from your nearest medical stores according to the prescription.

How Long Can Opana ER Last in the System

The Opana ER tablets are formulated for slowly releasing the active drug so that its pain relief effects last for 12 hours. But the active drug from each extended-release tablet can still stay in your system active for up to 24-48 hours before it has been broken down by the liver. After that, it is excreted out in your urine and stool. Most of the drugs will leave your system after five days.

Available Variants of Opana ER

Overdose Symptoms

  • Difficulty in breathing and other respiratory problems
  • Bluish tinges on skin, lips, or fingernails
  • Cold, dry, and  clammy skin
  • Dilated pupils
  • Dark circles under the eyes
  • Weak muscles
  • Extreme sleepiness
  • Slowed heartbeat
  • Inability to respond or understand

In order to avoid any of these overdose symptoms, the concerned doctors recommend to buy Opana ER online to get the verified medicines. It is really crucial to get Opana ER or any other medicines online to ensure their originality.

Side Effects on Long-Term Use

In general, Opana ER is introduced for a short period of time. Using semi-opioid pain relief medications like Opana ER for the long term can induce several health issues and adverse effects on the individual using it. The side effects of using Opana ER tablets include:

  • Hives
  • Respiratory problems
  • Swelling of face, lips, tongue, etc.
  • Discoloration of lips
  • Shallow breathing,
  • Sleep apnea
  • Seizures
  • Chest pan
  • cough with yellow or green mucus,
  • Severe vomiting
  • Nausea
  • Loss of appetite
  • Dizziness
  • Tiredness
  • Agitation
  • Hallucinations
  • High fever
  • Sweating
  • Shaking and tremors
  • Faster heart rate
  • Stiffness in muscles
  • Loss of coordination, and
  • Diarrhea
  • Constipation
  • Severe headaches, etc.

Opana ER Drug Abuse and Addiction

When abused, Opana ER tends to slow down some of the functions of the central nervous system (CNS) that are related to the stress response, such as heart rate, blood pressure, breathing rate, and anxiety level within an individual. Even when this medicine is used exactly as prescribed for pain relief, an individual can develop a tolerance. Eventually, he/she becomes dependent on the Opana ER drug.

The risks for dependency are further increased when an individual is taking this drug for nonmedical purposes like getting high. Once someone becomes dependent on the Opana ER drug, medical detox is often considered the safest and smoothest way to get rid of the drug from the system. Suddenly stopping or discontinuation of Opana ER use can induce an opioid withdrawal syndrome.

An individual who is addicted to the Opana ER drug may find themselves not only physically dependent on it but emotionally dependent too. Emotional dependence can be characterized by:

  • Consistent drug-related thoughts
  • Fear of running low on the drugs
  • A significant time spending to acquire more drugs
  • Spending less time with friends and kins
  • Continuing to misuse the drug, even after knowing the consequences


When a patient no longer requires therapy using Opana ER for severe bodily pain, the dose should be gradually downward titrated every 2-4 days. This step is crucial in preventing signs and symptoms of withdrawal in the physically-dependent patient or individual. Abrupt discontinuation of Opana ER drug is not beneficial.

Any rapid or instant discontinuation of opioid analgesics in physically-dependent patients on opioids has resulted in serious withdrawal symptoms, uncontrollable severe pain, and suicidal attempts. Rapid discontinuation has also been associated with drug-seeking activities for abuse and misuse. Patients may also attempt to buy Opana ER online without a prescription.

The most commonly observed symptoms of drug withdrawal include:

  • Agitation
  • Anxiety
  • Trouble while sleeping
  • Muscle twitching
  • Excessive sweating, etc.

Drug Interactions

The risk of serious side effects may be increased when Opana ER medication is taken along with other products that may also cause drowsiness or breathing problems. Inform your doctor or pharmacist beforehand if you are using any other products such as:

  • Other opioid pain or cough medicines such as Codeine, Hydrocodone, Oxycontin, etc.
  • Alcohol
  • Marijuana or other cannabis products
  • Anxiety pills or sleep-promoting pills such as alprazolam (Xanax), Lorazepam, Zolpidem
  • Muscle relaxants such as carisoprodol, and cyclobenzaprine
  • Antihistamine medicnes such as cetirizine, and diphenhydramine

Opana ER Usage During Pregnancy

  • Prolonged use of opioid medications during pregnancy can result in physical dependence in the neonate. Pregnant women should be enlightened about the risk of neonatal abstinence syndrome. Long-acting opioids should not be used during and immediately prior to labor
  • Breastfed infants must be monitored regularly for excess sedation and respiratory depression.
  • Due to the potential for serious adverse reactions breastfeeding is not recommended while using the oxymorphone extended-release tablets.