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Tramadol is an effective medication globally prescribed by thousands of doctors to treat moderate to severe pain including pain after surgery or serious accidents. It is an opiate (narcotic) analgesic and a controlled substance. That is why you will need a valid prescription to buy Tramadol online or over the counter. We are here to discuss Tramadol’s effectiveness in treating chronic and acute pain and much more.

Details on Tramadol

Tramadol drug is a strong pain reliever used for the treatment of moderate to severe pain that is not being relieved by other pain medicines effectively. This medicine is a synthetic opioid and affects the brain and the central nervous system (CNS).

The Tramadol drug is available for general public use under the trade name  Ultram, Ultram ER, and Conzip. The extended-release form of Tramadol capsules or tablets is generally used for around-the-clock treatment of chronic ongoing pain therapy.

Most of the Tramadol medicine supplied to the market is manufactured by several pharmaceutical agencies in various different formulations:

  • Capsule (Immediate Release)
  • Solution
  • Tablet (Immediate Release)
  • Tablet (Extended Release)
  • Capsule (Extended Release)
  • Suspension

You can order Tramadol for these variants available on our BigpharmUSA website:


Tramadol works on the opioid pain receptors present in an individual’s brain and throughout the central nervous system. It also slightly inhibits the reuptake of two neurotransmitters namely Serotonin and Norepinephrine.

The pain relief effects begin about an hour after the dose is taken. Effects of Tramadol drug peak in 2-4 hours. There is also an extended-release version of Tramadol supplied that dispenses dosage in phases over a longer time period. That is, a single extended-release pill acts longer in an individual’s system.

The half-life of Tramadol drug in the bloodstream is between 5-9 hours. This period may be even longer for individuals using multiple doses of Tramadol. The drug takes about 5-6 times as long as the half-life for complete elimination from the system.

Tramadol is broken down or metabolized in the liver and excreted mostly by the kidneys through urination. About 30% of the Tramadol dose is excreted unchanged. The rest of it is converted into multiple metabolites.

Proper Dosage of Tramadol

  • For Chronic Pain:

Adult Dosage  (Extended-Release capsules and tablets):

At first, 100 mg of Tramadol is prescribed to be used once every day. Your doctor may increase the dose depending on the response to the treatment. However, the dose of Tramadol drug should not exceed 300 mg per day.

  • For moderate to severe pain:

Adult Dosage (Immediate-Release tablets and capsules):

Adults and children above the age of 16 years are prescribed to take 50-100 mg of Tramadol every 4-6 hours for severe pain relief. The doctor may change the dose as per requirements. However, the dose should not be more than 400 mg a day.

Geriatric Dosage (Immediate-Release tablets and capsules):

Older adults over the age of 75 years must use 25 mg of Tramadol drug every day, in the morning. Your doctor may increase the dose of Tramadol as per the need and tolerance of the patient. Any dose of more than 300 mg per day is not recommended for older individuals.


To prevent an overdose of Tramadol drug, you should only take the exact amount prescribed dose. It is dangerous to crush or cut the Tramadol tablets or capsules as may release a larger dose into the system all at once. To avoid overdosing on any drug, you need to use the prescription strictly and get Tramadol accordingly.

Tramadol tablets and capsules are available both online and over the counter. Anyone can buy Tramadol online with a proper prescription. Overdose symptoms of Tramadol include:

  • Decreased awareness
  • Slowed responsiveness
  • Difficulty while breathing
  • Feeling lightheaded
  • Loss of consciousness
  • Constricted pupils
  • Severe drowsiness
  • Irregular heartbeat
  • Cold or clammy skin
  • Unusual tiredness, etc.

Observed Side Effects of Using Tramadol

  • Headaches
  • Feeling sleepy, tired, and dizzy
  • Feeling sick, nausea, and vomiting
  • Constipation
  • Dry mouth
  • Sweating
  • Getting low blood pressure
  • Have hallucinations
  • Feeling confused
  • Having trouble while urinating
  • Stomach pain or cramps
  • Itching
  • Seizure
  • Weak pulse, etc.

Some of these side effects may occur that do not need any special medical attention. These side effects may go away during the therapy as your body adjusts to Tramadol medicine. Also, your health care professional may be able to provide solutions on how to prevent these side effects.

Stay in touch with your health care professional and inform them immediately if any of these side effects continue to bother you.


The presence of certain specific health conditions or medical problems may affect the working and efficacy of Tramadol medicine. It is really important to know when to use the Tramadol tablets. Before you opt to buy Tramadol online, make sure to inform the concerned doctor whether you have any of the following medical conditions:

  • Adrenal problem
  • A history of alcoholism or drug abuse
  • Brain tumor or any head injury
  • Depression
  • Diabetes
  • Gallstones
  • Hormonal problems
  • Any infections of the central nervous system
  • Breathing problems
  • Sleep apnea
  • Mental illness
  • Phenylketone allergy
  • History of having seizures or epilepsy
  • Stomach or abdominal problems
  • Any kidney disease
  • Liver disease
  • Lung problems like asthma or hypercapnia
  • Stomach or bowel blockage or Paralytic ileus
  • Had a recent surgery
  • Phenylketonuria, etc.

Interactions With Other Drugs

There are a variety of medications and substances that can interact with Tramadol adversely. Either these substances can affect the working of Tramadol on an individual or amplify certain side effects to dangerous levels. It is highly recommended to reduce the dosage of the following medications or stop using them along with Tramadol after consulting with your doctor:

  • Medicine for allergies, blood pressure, motion sickness
  • Medications for asthma or other respiratory disorders
  • Other opioid medicines like Hydrocodone, Oxycodone, etc.
  • Benzodiazepine sedatives like Valium, Klonopin, Xanax, etc.
  • Sleeping medicines and muscle relaxers
  • Other antidepressants or stimulants
  • Medicine for Parkinson’s disease
  • Medicines for migraine, headaches
  • Medicine for any serious infection
  • Alcohol, cannabis products, etc.

Abusing Tramadol and its Addiction

Tramadol is often available as a prescribed medication because it has less addictive potential as compared to other opioid painkillers. Often people buy Tramadol online knowing that most painkillers are Schedule II controlled substances under the Controlled Substances Act, while Tramadol is a Schedule IV substance.

Tramadol is generally abused for its calming and euphoric effects. Individuals using Tramadol usually feel relaxed and happy. People suffering from severe pain may also take higher doses of the drug. Frequent Tramadol users might become addicted and seek for illicit drugs to satisfy their cravings.

Tramadol dependence occurs when it is used for longer periods of time or at higher doses. While using Tramadol for a long time an individual’s brain can get used to its effects, this is known as tolerance. As an individual develops tolerance, they may begin to need a higher dose to experience the same effects as before.

Signs of Tramadol Addiction:

  • Getting excited about thinking of Tramadol tablets and worrying about how much is left.
  • Using more than the prescribed dose, without a doctor’s approval
  • Going out on ‘Doctor Shopping’
  • Buying Tramadol capsules from illicit sources or switching to other narcotics
  • Lying about Tramadol usage
  • Making unsuccessful attempts to quit Tramadol
  • Cravings for Tramadol drug
  • Experiencing frequent mood swings
  • Experiencing excessive sleepiness
  • Having chronic constipation
  • Experiencing more intense side effects from using the medication

After repeatedly using Tramadol medicine, people may develop a physiological dependence. When dependence develops, Tramadol medication should not be stopped abruptly. In doing so, an individual may experience a range of potentially uncomfortable withdrawal symptoms.

Withdrawal Symptoms:

  • Feeling agitated
  • Feeling anxious or nervous
  • Tremors and shaking in limbs and body parts
  • Unusual sweating
  • Pain in joints and muscles
  • Loss of appetite
  • Nausea
  • Vomiting
  • Abdominal cramps
  • Diarrhea, etc.