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Morphine vs Vicodin: What’s The Difference?

Morphine vs Vicodin

Pain relief medications are commonly used for treating various pain conditions and for other medical purposes as well. The Food and Drug Administration (FDA) has approved Vicodin and Morphine medication, which are used to treat several types of pain. These medications help to prevent many health conditions like severe back pain, physical pain, and many more. In this article, you will get the difference between Morphine vs Vicodin on the basis of their availability, functions, dosage, and side effects.

What are Morphine and Vicodin Medications?

Here is a detailed review of Morphine and Vicodin medicines.

Morphine medication

Morphine is a prescription-only drug useful in treating mild or severe pain. It belongs to the group of medications known as opioid (narcotic) analgesics. This medication works in the brain to change how you feel and respond to pain in the body. This drug is prescribed for treating Chronic Pain, Neonatal Abstinence Syndrome (NAS), and several other pain complications.

Vicodin Medication

Vicodin drug is prescribed by doctors to their patients and is used for the management of moderate to severe pain in individuals. It acts in the Central Nervous System (CNS) to relieve pain.

This medicine is also used to relieve severe back pain. It belongs to the category of Schedule II controlled substance drug. This drug is a combinational substance of Hydrocodone and Acetaminophen.

Comparison between Morphine and Vicodin Medicines

Based on variables, Vicodin and Morphine may differ from each other. Here are the differences between these two medications:


Vicodin is available in the form of oral tablets while Morphine is available in the form of oral solutions, tablets, injections, ER (Extended-Release) tablets, ER (Extended-Release), and oral capsules.


Morphine and Vicodin medicines are prescribed for treating various kinds of pain whether it is mild, moderate, or severe. Do not take these drugs without a doctor’s prescription as using this medication on your own can cause adverse effects. The half-life of both Vicodin and Morphine is around 4 hours.

Dosage Information

These medicines dosages are administered by doctors for treating pain that may caused by pre or post-surgery, operation, etc.

The Vicodin medicine dosage is prescribed for Back Pain, Rheumatoid Arthritis, and many others. Morphine drug dosage is administered by healthcare experts for treating Chronic Pain, Neonatal Abstinence Syndrome, and various other symptoms that can cause pain. Doctors can increase or decrease the dosage of Vicodin and Morphine medicines after monitoring the patients.

Vicodin Dosage Strength and Forms:

Mentioned below is the dosage strength along with the form of Vicodin medication.

Oral tablet:

  • 2.5 mg / 325 mg
  • 5 mg / 300 mg, 5 mg / 325 mg
  • 7.5 mg / 300 mg, 7.5 mg / 325 mg
  • 10 mg / 300 mg, 10 mg / 325 mg

Oral solution:

  • (7.5 mg / 325 mg)/15 ml
  • (10 mg / 300 mg) /15 ml, (10 mg / 325 mg) / 15 ml.

Morphine Dosage Strength and Forms:

There are varied dosage strengths and forms of morphine drug. Let’s take a look at the that are included below:

Tablet, extended-release (abuse-deterrent):

• 15 mg, 30 mg and 60 mg
• 15 mg, 30 mg, 60 mg and 100 mg.

Capsule, morphine sulfate extended-release:

• 10 mg, 20 mg, 30 mg, 45 mg, 50 mg and 60mg
• 75 mg, 80 mg, 90 mg, 100 mg and 120mg.

Morphine sulfate, injectable solution:

• 0.5 mg / ml, 1 mg / ml, 2 mg / ml, 4 mg / ml and 5 mg / ml
• 8 mg / ml, 10 mg / ml, 15 mg / ml, 25 mg / ml and 50 mg / ml.

Health conditions – When people take Morphine and Vicodin drugs, they can suffer from many health conditions such as dizziness, loss of consciousness, increased sleepiness, nausea, difficulty in breathing, cold and clammy skin, low blood pressure, etc.

Side Effects of Morphine and Vicodin

Here are some common side effects of Morphine and Vicodin drugs.

Adverse Effects of Morphine Drug:

Here are some common side effects of Morphine medication:

  • Blurred vision
  • Confusion
  • Chills
  • Reduced urination
  • Cough
  • Fainting
  • Nausea
  • Vomiting
  • Agitation
  • Tarry stools
  • Fever
  • Twitching
  • Overactive reflexes
  • Slow heartbeats
  • Blue or pale lips
  • Depression
  • Increased thirst
  • Extreme drowsiness
  • Weight gain
  • Dry mouth
  • Night blindness
  • Abnormal dreams

Adverse Effects of Vicodin Drug:

The most common side effects of Vicodin medication such as:

  • Light-headedness
  • Anxiety
  • Dizziness
  • Vomiting
  • Nausea
  • Drowsiness
  • Constipation
  • Blurred vision
  • Mood swings
  • Upset stomach
  • Difficulty when urinating
  • Dry mouth
  • Ringing in your ears
  • Fast heartbeat
  • Nervousness


  • Do not drive after taking Vicodin and Morphine.
  • Before you start taking these medicine tell your doctor if you have any other drug allergies.
  • Keep the medicines away from the reach of children and pets.
  • You should not take these medications while using other medicines without the consultation of your doctor.
  • Do not drink alcohol because it can interact with Morphine and Vicodin drugs, and that may lead to death.
  • These medications should make you feel dizziness and drowsiness.
  • Doctors do not administer Morphine and Vicodin to pregnant women.
  • Never share the dose of these drugs with others.

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