Each sublingual tablet of Suboxone 8 mg contains 8mg of buprenorphine hydrochloride and 2mg of naloxone hydrochloride dihydrate. Buprenorphine drug is a partial agonist that affects the mu-opioid receptor and an antagonist acting at the kappa-opioid receptor while Naloxone is an antagonist working at the mu-opioid receptor.
Buprenorphine hydrochloride can be identified as a white powder-like substance, that is weakly acidic with limited solubility in water. Whereas, Naloxone hydrochloride drug is available as a white to slightly off-white powder and is soluble in water, in dilute acids, and in strong alkali. Buprenorphine drug is classified as a Schedule III narcotic under the Controlled Substances Act and thus Suboxone is also listed under the same class.
Suboxone medicine is supplied as uncoated hexagonal orange-colored tablets intended for sublingual administration. It is available in two dosage strengths, Suboxone 2 mg (2 mg buprenorphine with 0.5 mg naloxone), and Suboxone 8 mg ( 8 mg buprenorphine with 2 mg naloxone). Apart from tablets, Suboxone is also available as an oral strip or film.
Working in The System
Buprenorphine is able to exert agonistic effects at mu and delta opioid receptors in CNS (Central Nervous System) while the Naloxone drug produces opioid withdrawal signs and symptoms in individuals who are physically dependent on full opioid agonists. After taking the Suboxone 2 mg tablets, the medication takes about 1-2 hours to reach peak concentration in the bloodstream. Then after, the Buprenorphine drug present in Suboxone is metabolized by N-dealkylation via CYP3A4 to norbuprenorphine and by glucuronidation but then Naloxone drug is metabolized by direct glucuronidation to naloxone-3-glucuronide. After metabolization and absorption from the gastrointestinal tract, residual Suboxone is eliminated from an individual’s system via urine and feces. In about 1-2 days (24-42 hours) Suboxone dose will be completely eliminated from an individual’s system.How to Use Suboxone Pills
At the beginning of the treatment, Suboxone tablets must be taken under the supervision of an authorized doctor who has appropriate experience in managing opioid addiction. The effectiveness of the Suboxone 8 mg pill primarily depends on the individual’s health conditions, social, and psychological support.Proper Dosage
- Whatsoever, the Suboxone tablets should never be swallowed directly, rather they should be placed under the tongue and allowed to dissolve gradually.
- An individual may start the treatment with an initial dose of Suboxone 2 mg /0.5 mg. This dose may be further optimized by the doctor depending on the patient’s response to Suboxone medicine.
- Never stop using Suboxone (buprenorphine and naloxone) suddenly, as you could have unpleasant withdrawal symptoms. Consult your concerned doctor before ending the treatment with this medicine.
- The daily dose should not exceed 24 mg of buprenorphine. Once the individual’s system is observed to be stabilized, the maintenance dose of Suboxone may be reduced gradually, and eventually, the treatment can be stopped.
Missed Dose and Overdosing on Suboxone
Take the missed dose of Suboxone 8 mg medicine as soon as you can, but you may skip the missed dose if it is almost time for the next dose. Never take multiple doses at a time. For further advice stay in touch with your concerned doctor. An opioid drug overdose situation may arrive when an individual takes an inappropriate dose of Suboxone in a day. This can be fatal, especially in children or any individual using the medicine without a prescription. Overdose symptoms may include severe drowsiness, constricted pupils, slow breathing, etc. To avoid any such overdose symptoms it is crucial to follow the prescription for dosage and the concerned doctor’s advice.Do Not Co-Administer Suboxone 8 mg with:
- Sedatives such as benzodiazepines or related products should be prohibited along with Suboxone. The simultaneous use of opioids with sedative medicinal products such as Xanax (alprazolam), Klonopin (clonazepam), Valium (diazepam), Ativan (lorazepam), and Restoril (temazepam) may increase the risk of sedation, respiratory depression, coma, and even death.
- Serotonergic medicinal products, such as MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants. These might increase the risk of serotonin syndrome.
- Alcohol, marijuana, and other narcotic products can promote severe sedation and drowsiness when taken along with Suboxone 8 mg tablets.
- Certain antibiotic medicines like Biaxin (clarithromycin) and Ery-Tab (erythromycin)
- Antidepressants, including Prozac (fluoxetine) and Nardil (phenelzine)
- St. John’s wort, HIV medicines, etc.
Suboxone 8 mg During Pregnancy
At the final stage of pregnancy, Buprenorphine (Suboxone) may induce respiratory depression in the newborn infant. Long-term administration of this drug during the last three months of pregnancy may cause withdrawal syndrome in the neonate. Furthermore, an individual may use Suboxone 8 mg during pregnancy only after assessing its potential benefits. It is unknown whether the Naloxone drug is excreted in human milk or not, but studies show that Buprenorphine and its metabolites are excreted in human milk. Therefore, breastfeeding should be discontinued during treatment with Suboxone 8 mg pills or vice versa. Suboxone medicine should only be approved for breastfeeding mothers if its potential benefits outweigh the potential risk to the infant.Related Product
-
Generic Suboxone 2 mg
Rated 4.42 out of 5$508.00 – $1,507.00
Winnona Hemmings –
I always prefer buying medicines online. In the near past, I got to know about this website. After analyzing and buying from this website I can say that this is a great site to buy medicines safely. They only provide original and legal medicines so there are no reasons to worry.
Tamara Queen –
Suboxone pills of 8 mg and 2 mg, along with Suboxone strips are available on BigpharmaUSA for all. This is a one-stop shop to get all the medicines at affordable prices. One of their best features is that they put up sale on different products at different times of the year.
Marry Popins –
8 milligram Suboxone tablets are the highest dose anyone can avail of on this website. They do miss out on some of the other variants but they compensate with their outstanding services and delivery mechanism.
Liam Paul –
I got the generic Suboxone 8 mg pills at an unbelievable price. I can bet you cannot find Suboxone medicines at such low prices. Thank you BigpharmaUSA for providing them for so cheap. From now on I even recommend my relatives to get their prescribed medicine from here.
Stuart Wilde –
A few days from now I ordered Suboxone tablets 8 mg for one of my friends. Interestingly this website provides legal medication with a proper prescription only. I liked this feature a lot. This will definitely restrict abusers.
Oliver Twist –
Thank you BigpharmaUSA for delivering my meds always on time. I feel blessed visiting their website every time as they fulfill all my needs. I recommend all my friends order their meds from here.
Genna Atterton –
Suboxone 8 mg orange pills are very potent medicine used for opioid withdrawal. I was unable to find these pills until I came across this website. This website supplies all the medicines I need.
Philip Young –
Buprenorphine 8 mg/ Naloxone 4 mg are plenty available on this website. These pills are also referred to as Suboxone 8 mg. They also supply the sublingual films of Suboxone with a prescription. I buy from this site most of the time due to their attractive discount features.
Connei Williams –
All forms and variants of Suboxone including Suboxone 8 mg tablets and films are supplied on the BigpharmaUSA website. I was shocked to see such a wide variety of medicine all at one site. They are famous for their customer service apart from original medications.
Pricila Manque –
Buprenorphine HCl 8 mg tablets present on the BigpharmaUSA website are about to be stocked out. Go get them now or wait until the stock is replenished. It might take a while, so grab all still you can.